Cancer Guide Analysis

Structural Analysis Guide

Everyone’s Guide for Cancer Therapy

Carcinoma of the ovary is one of the most common gynecologic malignancies. In many cases, it is curable when found early, but because it does not cause any symptoms in its early stages, most women have widespread disease at the time of diagnosis. Partly because of this, the mortality rate from ovarian cancer exceeds that for all other gynecologic malignancies combined. It is the fourth most fre...

Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer , Breast Cancer

The widespread introduction of high throughput RNA interference screening technology has revealed tumour drug sensitivity pathways to common cytotoxics such as paclitaxel, doxorubicin and 5fluorouracil, targeted agents such as trastuzumab and inhibitors of AKT and Poly(ADP-ribose) polymerase (PARP) as well as endocrine therapies such as tamoxifen. Given the limited power of microarray signature...

Management of Febrile Neutropenia in Children with Cancer; a Practical Guide to Diagnosis and Treatment

This study aimed to provide an evidence-based guideline for the clinical management of febrile neutropenia in children with cancer. In this narrative review, the most recently published sources of information on febrile neutropenia consisting of textbooks and articles, have been reviewed. We focused on the more recent data about diagnosis, treatment and management in children through the use o...

Uncertainty Analysis A practical guide

During the DELPHI project a first attempt was made to standard-ise the way uncertainty analysis was carried out. However, some of the documents that were produced contain errors w.r.t. the treatment of systematic errors and could easily lead to a misinterpretation of the underlying theory. Therefore Philips Research and CQM decided to produce a document that deals with this subject in a more pr...